Missouri Cities Rank Best in Midwest for Startups

Multiple Missouri cities topped the list in a new report of the best Midwest cities for startups published by M25, an early-stage venture firm based in Chicago. M25 evaluates cities based on multiple factors, including startup activity, access to resources and business climate.

St. Louis, Missouri, ranked 5th best for the second year in a row. Missouri’s St. Louis region, and the 2.1 million people who call it home, is a hub of innovation and entrepreneurship, recognized globally as a leader in agtech, financial services, advanced manufacturing, defense, health innovation and distribution.

Kansas City, Missouri, ranked 12th best in the Midwest for the second year in a row. The Kansas City region sits on the Missouri River at the crossroads of four major interstates, three major highways, five Class 1 rail lines, and is served by the Kansas City International Airport. This combination of logistical assets offers direct connections to markets across North America and around the world.

Other Missouri cities on the list include Columbia (28th), Springfield (39th) and Jefferson City (56th). You can check out the full report for 2021 here.

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