St. Louis, now more than 2.8 million residents strong, earned its reputation as a central Midwestern hub on the Mississippi River in Mark Twain’s river stories.
It continues to be a logistics haven with great water access. Kansas City, deep in the Midwest farm belt, is located on Interstates 70 and 35, making east-west and north-south access easy, and is also a major rail hub that hosts an international airport. St. Louis recently ranked No. 21 and Kansas City ranked No. 35 in Global Trade’s “Top 50 Cities for Global Trade.