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The Northeast region - A very storied place

Truman State UniversityOverlooking HannibalMark Twain RiverboatJackson Country Connection in La PlataHannibal's Main StreetHannibal-LaGrange College
Click on a photo to enlarge.

One of the world’s most beloved authors hailed from Missouri’s northeast corner.  More than a century later, the state’s largest lake and national forest lands still bear his name: Mark Twain.

Not surprisingly, Mark Twain grew up along the Mississippi River, which runs along Missouri’s eastern border, creating a low-cost shipping option for the region’s manufacturers.  Four Class I rail carriers and two interstate highways (I-70 and I-72) contribute to the area’s logistical assets. Four-lane US-36 provides one of the fastest, least congested truck routes between Kansas City and Chicago.

Twain’s hometown of Hannibal is but one of a handful of cities dotting the 16-county area.  Moberly, located on the region’s western edge, boasts one of Missouri’s biggest municipal parks, the largely forested 447-acre Rothwell Park.  Kirksville, just north of Moberly, is home to nationally-ranked Truman State University, as well as A.T. Still University, the birthplace of osteopathic medicine.   

A prolific producer of soybeans, the northeast is also strong in manufacturing, food processing, alternative energy and transportation/logistics.  Companies look to the region for low land and labor costs, as well as these other state-wide benefits:

  • Low business costs and taxes
  • An above-average, below-market workforce
  • A low cost of living
  • A strong transportation network:
    • Interstates 70 and 72, Highways 24, 36, 54, 61 and 63
    • Class I rail via BNSF, NS, KCS and UP
    • Regional airports
    • Mississippi River access

Major Cities

Hannibal: (Pop: 17,883)
Kirksville: (17,577)
Moberly: (13,746)
Warrenton: (8,039)

Source: U.S. Census Bureau, 2013







Businesses and Industry

The region's major employers include:

Northeast Missouri profile

Educational attainment:

High School Diploma  71,991
Some College 38,483
Associate's Degree 12,175
Bachelor's Degree 17,346
Graduate Degree 9,717
Total Degrees 149,712

Download data (Excel or PDF) for all Missouri counties and regions.

Population 2014:  268,315
Population Projection 2030 321,941
Civilian Labor Force (July 2015) 268,315
Employment (July 2015) 122,142
Unemployment (June 2014) 7,825
Unemployment Rate (June 2014) 6.00%

Download data (Excel or PDF) for all Missouri regions and counties.

Recent investment projects

The northeast region has successfully supported new business expansion in recent years.  Companies include:

  • Uncle Ray's - new production facility to create 110 jobs
  • Lakeview Energy - adding 19 jobs
  • Mid-Am Building Supply - expansion of manufacturing and distribution operation
  • Onshore Outsourcing - 100 new IT services jobs
  • Enduro industries - adding 24 jobs
  • Bodine Aluminum - castings for Toyota Motor Corp. 
  • Hartzell - hardwood products
  • Calumet Specialty Products Partners - specialty hydrocarbons 
  • CertainTeed - residential roofing shingles

Next steps

Download regional data  or find available sites and buildings in the region.

Related downloads

Related maps

Local economic development contacts


Northeast Missouri Development Partnership (Montgomery, Randolph,  Monroe, Ralls, Marion, Shelby, Macon, Lewis, Knox, Adair, Schuyler, Scotland, and Clark Counties)

St. Louis Regional Chamber (Warren and Lincoln Counties)


Hannibal Missouri Chamber of Commerce

Kirksville Regional Economic Development, Inc.

Moberly Area Economic Development

Northeast Missouri Economic Development Council

Pike County Development Authority


Contact Us
Phone: +1.314.725.0949
Toll Free: +1.877.725.0949
Fax: +1.314.725.0743
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120 South Central Avenue, Suite 1535
Saint Louis, MO 63105

12200 NW Ambassador Drive, Suite 205
Kansas City, MO 64163