In addition to being home to some of the most prestigious hospitals, medical schools, and health services companies in the country, Missouri has established organizations such as the Missouri Technology Corporation that facilitate health technology transfer, providing infrastructure needed to support health innovation.

Missouri has four research hospitals, three of which are teaching hospitals and are ranked by U.S. News and World Report:

• Barnes-Jewish Hospital in St. Louis is a teaching hospital and a 1,196 bed general medical and surgical facility with several specialties, 15 of which have been ranked, including 9th nationally in Orthopedics and 8th in Pulmonology.
• Children's Mercy Hospitals and Clinics in Kansas City is a 260-bed children's general facility and teaching hospital with ten ranked pediatric specialties, including 10th in Nephrology.
• St. Louis Children's Hospital is a 250-bed children's general facility that serves as a teaching hospital and has ten ranked pediatric specialties, including 5th in Neurology and Neurosurgery and 6th in Pulmonology.
• St. Luke's Hospital is located in Kansas City and has 404 beds. In 2010, St. Luke's was awarded the Missouri Quality Award from the Excellence in Missouri Foundation.

Other major Missouri hospitals include:

Boone Hospital Center (Columbia)

CoxHealth (Springfield)

Fulton State Hospital

St. Mary's Health Center (Jefferson City)

Mercy Springfield

University of Missouri Health System (Columbia)

Missouri has 6 medical schools, including Washington University in St. Louis, ranked 4th by U.S. News and World Report:

• A.T. Still University
• Kansas City University of Medicine and Bioscience
• Saint Louis University
• University of Missouri-Columbia
• University of Missouri-Kansas City
• Washington University in St. Louis

Cerner Corporation: (HQ Kansas City) Cerner is the leading U.S. provider of health care information technology solutions.

ClearPractice: (St. Louis) ClearPractice started in 1999 as a software company with an electronic prescribing product and later added electronic health records and most recently, a product called Nimble to allow doctors to manage patient information by connecting their iPads to data centers managed by ClearPractice. The company now has nearly 500 doctors using its software.

Express Scripts: (HQ St. Louis) Express Scripts is a pharmacy benefit management firm that processes prescription drug claims and manages drug plans for government agencies, private firms, and unions. It is the largest company headquartered in the St. Louis region, employing nearly 4,000 people.

Missouri Technology Corporation: (Jefferson City) The Missouri Technology Corporation is a private, non-profit entity established to enhance and expand the potential for technologically-based employment to drive Missouri's job growth in the coming decades. MTC oversees the operations of ten Innovation Centers in the state, works closely with the University of MIssouri and the Missouri Federal and State Technology Program, and provides grants and direct seed capital to businesses and organizations that conduct significant research and development or demonstrate the promise of growth or job creation.